郑州痛风专科医院：研究显示非洲裔美国人的高血压与血尿酸关系密切

　　维克森林大学Baptist医学中心最近发现，非洲裔美国人血尿酸水平的升高与高血压密切相关，这表明简单的血液检测可以预测高血压的风险，降低尿酸可能成为降低高血压相关并发症的新治疗方法。这项研究发表在美国心脏病协会的《Hypertension》杂志上。

 

　　内科副教授医学博士理学硕士PhilipB.Mellen是该研究的领导者，他说：我们的研究发现尿酸和高血压在黑人中的相关性更强，而黑人患有肾脏疾病，中风和其他高血压并发症的比例也更高。

 

　　郑州痛风专科医院介绍说尿酸水平受饮食因素(如高蛋白饮食)和体内细胞分解的影响。大部分尿酸从尿液中排出。若尿酸产生过多或肾脏排泄尿酸能力下降，则会导致血尿酸水平升高。

 

　　尿酸水平过高会引起痛风，但最近的动物和人体研究表明，尿酸水平适度升高是高血压的原因之一。目前，研究人员正在研究降低尿酸是否可以预防高血压。

 

　　如果研究表明降低尿酸能有效治疗高血压，那么根据我们的研究结果，别嘌呤醇等降尿酸药物可能更适合黑人。

 

　　说。以前的研究发现，高尿酸血症与高血压有关，但这些研究不包括足够的黑人。本研究的数据来自ARIC研究(社区动脉粥样硬化风险研究)。

 

　　共有9104名参与者，年龄在45-64岁之间，平均年龄为53岁。所有参与者在研究开始时都没有高血压，在随访过程中，每三年需要接受四次以上的体检，以确定是否有高血压。统计分析显示，尿酸水平最高的四分组高血压风险增加约15%，调整年龄、基础血压、体重指数、肾功能、糖尿病、吸烟等影响因素的结果仍然如此。黑人男性中尿酸与高血压的相关性尤为明显。

 

　　与最低四分组男性黑人相比，尿酸水平最高的男性黑人患高血压的风险增加了两倍。在黑人妇女中，与最低四分组相比，高血压的风险增加了30%。Mellen说：经过九年多的随访研究，发现血尿酸水平与高血压呈正相关，在黑人中更为突出。

 

　　目前需要更多的研究来证实高尿酸的临床后果，尤其是黑人。

 

　　Source: Wake Forest University Baptist Medical Center Date: November 3, 2006 Study Shows Strong Link Between Uric Acid And Hypertension In African Americans New research shows that higher levels of uric acid are strongly associated with high blood pressure in African Americans, suggesting that a simple blood test could predict risk and that treatments to lower uric acid may be a novel way to reduce hypertension-related complications in this population. "The novel angle of our study is that the association between uric acid and hypertension is much stronger in blacks, a group that disproportionately suffers from kidney disease, stroke and other complications of hypertension," said Philip B. Mellen, M.D., M.S., assistant professor internal medicine, and lead investigator. The results are reported online in Hypertension, a journal of the American Heart Association.

 

　　Uric acid levels are influenced by dietary factors, such as high levels of protein, and by the breakdown of the body's cells. Most uric acid is eliminated in urine. However, if excess uric acid is being produced or if the kidneys cannot remove enough of it, levels build up in the blood. Very high levels of uric acid cause gout, but recent animal and human studies suggest that modest elevations of uric acid are one cause of hypertension.

 

　　Currently, studies are under way to evaluate whether lowering uric acid prevents hypertension. "If these studies show that lowering uric acid is an effective treatment, our research suggests that it may be especially appropriate for blacks," said Mellen. Uric acid can be lowered by medications such as allopurinol and newer agents under development. Previous studies have linked high levels of uric acid and hypertension, but they did not include a large number of blacks.

 

　　For the current study, researchers evaluated data from the Atherosclerosis Risk in Communities study. The 9,104 participants were free of hypertension when the study began. They were evaluated for hypertension at three-year intervals over four examinations. At the start, participants were between 45 and 64 with a mean age of 53 years. A statistical analysis revealed that overall, uric acid levels in the highest quartile increased the risk of hypertension by about 15 percent. These results held true even after adjusting for other variables that could have affected results, such as age, baseline blood pressure, body mass index, kidney function, diabetes and smoking.

 

　　The link between uric acid and hypertension was particularly strong among black men. Black men in the highest quartile had a two-fold risk of developing hypertension, compared to black men in the lowest quartile. In black women in the highest quartile, the increase in risk was 30 percent, compared to black women in the lowest quartile. "Uric acid in the blood was positively associated with hypertension over nine years of follow-up, and this relationship was stronger in blacks than in whites," said Mellen. "More research is warranted concerning the clinical consequences of high uric acid, especially in blacks."